Targeted drug delivery is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. Targeted drug delivery seeks to concentrate the medication in the tissues of interest while reducing the relative concentration of the medication in the remaining tissues. This improves efficacy of the while reducing side effects. It is very difficult for a drug molecule to reach its destination in the complex cellular network of an organism. Targeted delivery of drugs, as the name suggests, is to assist the drug molecule to reach preferably to the desired site. The inherent advantage of this technique has been the reduction in dose & side effect of the drug. Research related to the development of targeted drug delivery system is now a day is highly preferred and facilitating field of pharmaceutical world. In this manuscript, the attempts that have been made to use either chemical modifications of drugs or the development of drug-nanoparticulate systems to reach these objectives will be reviewed and their advantages and drawbacks discussed, to define what should be the chemical, biophysical, and biological characteristics of an optimized system.
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